Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response
نویسندگان
چکیده
منابع مشابه
Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response
In eukaryotic cells, diverse stresses trigger coalescence of RNA-binding proteins into stress granules. In vitro, stress-granule-associated proteins can demix to form liquids, hydrogels, and other assemblies lacking fixed stoichiometry. Observing these phenomena has generally required conditions far removed from physiological stresses. We show that poly(A)-binding protein (Pab1 in yeast), a def...
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ژورنال
عنوان ژورنال: Cell
سال: 2017
ISSN: 0092-8674
DOI: 10.1016/j.cell.2017.02.027